Journal article
Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease
A Rembach, JD Doecke, BR Roberts, AD Watt, NG Faux, I Volitakis, KK Pertile, RL Rumble, BO Trounson, CJ Fowler, W Wilson, KA Ellis, RN Martins, CC Rowe, VL Villemagne, D Ames, CL Masters, AI Bush
Journal of Alzheimer S Disease | IOS PRESS | Published : 2013
DOI: 10.3233/JAD-121474
Abstract
Background: Several studies have reported that peripheral levels of copper and ceruloplasmin (CP) can differentiate patients with Alzheimer's disease (AD) from non-AD cases. The aim of this study was to determine the diagnostic value of serum copper, CP, and non-CP copper levels in a large cohort of AD subjects. Methods: Serum copper and CP concentrations were measured at baseline and at 18-months in participants from the Australian Imaging Biomarkers and Lifestyle Study of Ageing. Cross-sectional and longitudinal analyses were conducted using both univariate and multivariate testing adjusting for age, gender, total protein, and ApoE ε4 genotype status. Results: There was no significant diff..
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Funding Acknowledgements
Core funding for the study was provided by CSIRO, which was supplemented by "in kind" contributions from the study partners (see http://aibl.csiro.au/). The research was also supported by the Science Industry and Endowment Fund (see http://sief.org.au/), and the National Health and Medical Research Council (NHMRC) via the Dementia Collaborative Research Centres program (DCRC2). MHRI acknowledges funding support from the Victorian Government's Operational Infrastructure Support program. Pfizer International has contributed financial support to assist with analysis of blood samples and to further the AIBL research program. The McCusker Foundation has contributed financial and in-kind support to AIBL. Dr. Faux was supported by a National Health and Medical Research Council (NHMRC) training fellowship. Dr. Rembach was supported by the CSIRO Office of the Chief Executive (OCE) postdoctoral fellowship and the JO & JR Wicking Trust and the Mason Foundation facilitated through ANZ trustees.